A clinical trial for people recently diagnosed with glioblastoma (GBM)

A clinical trial is evaluating a new investigational approach that combines an oral medication with non-invasive, low-intensity ultrasound.

See if you are eligible

About the trial

What this clinical trial is evaluating

This clinical trial is testing a new investigational therapy for adults who have recently been diagnosed with glioblastoma (GBM). The approach combines an oral medication with low-intensity ultrasound delivered through a specialized treatment system. The goal is to learn whether activating a compound that naturally builds up in tumor cells may help doctors target cancer cells in a new way.

The investigational therapy for glioblastoma is added on top of the standard treatment most patients already receive (surgery, radiation, and temozolomide). All patients continue standard care.

This therapy is not approved, and its safety and effectiveness are still being studied.

How it works

A two-step process under investigation

Oral medication
Patients take a medication that causes certain compounds to build up more in brain cancer cells than in healthy brain cells.
Targeted ultrasound activation
After the medication is absorbed, low-intensity ultrasound is delivered from outside the head. Researchers are studying whether this activation process may affect glioblastoma cells while sparing surrounding healthy tissue.

Participation & Eligibility

What Participation Involves

If you’re eligible, participation may include:

Continuing standard glioblastoma treatment (radiation and temozolomide)
Monthly outpatient visits for the investigational therapy
MRI scans and routine follow-up
Ongoing check-ins with the clinical trial team

Participation is voluntary, and you may leave the trial at any time.

Who May Be Eligible

You may be eligible if:

You are 18 to 80 years old
You have been recently diagnosed with glioblastoma
You have had, or are planning to have, surgery
You are scheduled for or completing standard radiation and temozolomide
Your tumor began in the brain (not from another cancer)

Final eligibility is determined by the clinical trial doctors.

Start the Qualification Check

Please answer a few quick questions. It should take less than one minute.
If the answers suggest you may qualify, a member of the team will call you to discuss next steps.

Hearing from Participants

Individual patient experiences. Not medical advice. Investigational product.

Vinny’s Story: Choosing to Participate in a Clinical Trial

Christa’s Story: A Participant Perspective

Important Notice: The following videos present individual patient experiences from participants in Alpheus-sponsored clinical trials. These accounts reflect each individual’s unique experience and may not represent the experiences of other participants. Clinical responses vary, and no conclusions about safety or effectiveness should be drawn from these stories. The product discussed is investigational, is being studied in clinical trials, and has not been approved by regulatory authorities.

This content is for informational and educational purposes only and does not constitute medical advice. Any medical decisions should be made between a patient and their healthcare provider. The featured participants provided voluntary written consent, including HIPAA authorization, for the use of their image, voice, and story in accordance with applicable laws and regulations.

Questions?

If you have questions about the clinical trial, a team member can speak with you after the initial screening.

All clinical trial information shared here is general and for educational purposes only. Final eligibility and participation decisions are made by the clinical trial doctors.